Colorectal cancer pathways.
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This article has been cited by other articles in PMC. Methods A retrospective study of patients with small bowel cancers admitted to a tertiary emergency center, over the past 15 years.
Most small bowel cancers are revealed by a complication
Results There were 57 patients with small bowel cancer, representing 0. There were 37 Out of 57 patients, 48 There were 10 The most frequent neoplasms were gastrointestinal stromal tumor in 24 patients The prevalence of duodenal adenocarcinoma was Obstruction was the complication in adenocarcinoma in Conclusion Primary small bowel cancers are usually diagnosed at advanced stages, and revealed by a local complication of the tumor.
Their surgical management in emergency setting is associated to significant morbidity and mortality rates.
The diagnosis of these tumors is often delayed due to their nonspecific symptoms, usually being made during an acute complication of the disease. The secondary objectives were to determine early morbidity and mortality associated with surgical resection, and to correlate the pathology of the tumor with its clinical picture.
Article Introduction Colorectal cancer CRC is the third most common cancer in men and the second most common in women. Although screening, addressability and increased awareness have augmented the number of cases in the non-metastatic setting, approximately one in four individuals with CRC will be diagnosed in stage IV. Additionally, because this improvement in survival has also been associated with substantial health care financial burden, appropriate selection of patients for specific treatments is of utmost importance. Currently, there are several biomarkers that help clinicians in making the optimal treatment decision: KRAS, NRAS, BRAF mutations, human epidermal growth factor receptor 2 HER2 amplification and microsatellite instability MSI or mismatch repair MMRthey all play a significant role in the process, facilitating selection of the right treatment for the right patient.
The selection criteria were duodenal, jejunal or ileal tumor; and histopathological examination proving the small bowel malignant neoplasm. Continuous variables are expressed as mean ± standard deviation, and the categorical ones as number percent.
Categorical variables were compared by the χ 2 tests. The probability of rejecting the null hypothesis statistical significance was set at 0.
Microsatellite Instability Status in Colorectal Cancer
We also did an electronic search at the colorectal cancer pathways of the U. Only English language literature was selected for further analysis.
Electronic and colorectal cancer pathways cross-referencing was used further to find more relevant sources.
The mean age for males was 58± We observed a mean interval from onset of symptoms to surgical treatment of 73 days, with 2.